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Dr. rer. nat. Henrike Lucas

- Publikationen -

Dissertation

Caysa, H
: Untersuchungen zum Monitoring von Tumorxenograftmodellen mittels nicht-invasivem in vivo Multispektral-Fluoreszenzimaging (http://digital.bibliothek.uni-halle.de/hs/content/titleinfo/1630519)


Publikationen

Heinrich AK, Lucas H, Schindler L, Chytil P, Etrych T, Mäder K, Mueller T.
Improved tumor specific drug accumulation by polymer therapeutics with
pH-sensitive drug release overcomes chemotherapy resistance.

Mol Cancer Ther. 2016 Mar 3. pii: molcanther.0824.2015. [Epub ahead of print] PMID: 26939698

Etrych T, Lucas H, Janoušková O, Chytil P, Mueller T, Mäder K.
Fluorescence optical imaging in anticancer drug delivery.
J Control Release. 2016 Mar 28;226:168-81. doi: 10.1016/j.jconrel.2016.02.022.
Epub 2016 Feb 16. Review. PMID: 26892751

Surov A, Caysa H, Wienke A, Spielmann RP, Fiedler E.
Correlation Between Different ADC Fractions, Cell Count, Ki-67,
Total Nucleic Areas and Average Nucleic Areas in Meningothelial Meningiomas.

Anticancer Res. 2015 Dec;35(12):6841-6. PMID: 26637905

Widder M, Lützkendorf J, Caysa H, Unverzagt S, Wickenhauser C, Benndorf RA, Schmoll HJ,
Müller-Tidow C, Müller T, Müller LP.
Multipotent mesenchymal stromal cells promote tumor growth in distinct colorectal cancer cells
by a 1-integrin-dependent mechanism.

Int J Cancer. 2016 Feb 15;138(4):964-75. doi: 10.1002/ijc.29844. Epub 2015 Oct 1. PMID: 26356035

Mahal K, Biersack B, Caysa H, Schobert R, Mueller T.
Combretastatin A-4 derived imidazoles show cytotoxic, antivascular, and antimetastatic effects based on cytoskeletal reorganisation.
Invest New Drugs. 2015 Jun;33(3):541-54. doi: 10.1007/s10637-015-0215-9.
Epub 2015 Feb 14. PMID:25678082

Chytil P, Hoffmann S, Schindler L, Kostka L, Ulbrich K, Caysa H, Mueller T, Mäder K, Etrych T.
Dual fluorescent HPMA copolymers for passive tumor targeting with pH-sensitive drug release II:
Impact of release rate on biodistribution.

J Control Release. 2013 Dec 10;172(2):504-12. doi: 10.1016/j.jconrel.2013.05.008.
Epub 2013 May 19. PubMed PMID: 23697767.

Hoffmann S, Caysa H, Kuntsche J, Kreideweiss P, Leimert A, Mueller T, Mäder K.
Carbohydrate plasma expanders for passive tumor targeting: in vitro and in vivo studies.
Carbohydr Polym. 2013 Jun 5;95(1):404-13. doi:
10.1016/j.carbpol.2013.03.033. Epub 2013 Mar 15. PubMed PMID: 23618286.

Caysa H, Hoffmann S, Luetzkendorf J, Mueller LP, Unverzagt S, Mäder K, Mueller T.
Monitoring of xenograft tumor growth and response to chemotherapy by non-invasive in vivo multispectral fluorescence imaging.
PLoS One. 2012;7(10):e47927. doi: 10.1371/journal.pone.0047927. Epub 2012 Oct 24. PubMed
PMID: 23112873; PubMed Central PMCID: PMC3480443.

Schädlich A, Hoffmann S, Mueller T, Caysa H, Rose C, Göpferich A, Li J, Kuntsche J, Mäder K.
Accumulation of nanocarriers in the ovary: a neglected toxicity risk?
J Control Release. 2012 May 30;160(1):105-12. doi:
10.1016/j.jconrel.2012.02.012. Epub 2012 Feb 21. PubMed PMID: 22361117.

Hoffmann S, Vystrčilová L, Ulbrich K, Etrych T, Caysa H, Mueller T, Mäder K.
Dual fluorescent HPMA copolymers for passive tumor targeting with pH-sensitive drug release:
synthesis and characterization of distribution and tumor accumulation in mice by
noninvasive multispectral optical imaging.

Biomacromolecules. 2012 Mar 12;13(3):652-63. doi: 10.1021/bm2015027. Epub 2012
Feb 10. PubMed PMID: 22263698.

Hoffmann S, Vystrcilova L, Ulbrich K, Etrych T, Caysa H, Mueller T, Mäder K.
HPMA Copolymer Drug Conjugates with pH-sensitive Release: Noninvasive and Simultaneous Characterisation
of Carrier and Drug Model Biodistribution and Tumor Accumulation In Mice By Use of In Vivo
Multispectral Optical Imaging.

Polymers in Medicine. 2012. ISBN 978-80-85009-72-9.

Schädlich A, Caysa H, Mueller T, Tenambergen F, Rose C, Göpferich A, Kuntsche J, Mäder K.
Tumor accumulation of NIR fluorescent PEG-PLA nanoparticles: impact of particle size and human xenograft tumor model.
ACS Nano. 2011 Nov 22;5(11):8710-20. doi: 10.1021/nn2026353. Epub 2011 Oct 10. PubMed PMID: 21970766.

Caysa H, Metz H, Mäder K, Mueller T.
Application of Benchtop-magnetic resonance imaging in a nude mouse tumor model.
J Exp Clin Cancer Res. 2011 Jul 21;30(1):69. doi: 10.1186/1756-9966-30-69. PubMed PMID: 21777437;
PubMed Central; PMCID: PMC3158420.

Schädlich A, Rose C, Kuntsche J, Caysa H, Mueller T, Göpferich A, Mäder K.
How stealthy are PEG-PLA nanoparticles? An NIR in vivo study combined with detailed size measurements. Pharm Res. 2011 Aug;28(8):1995-2007. doi:
10.1007/s11095-011-0426-5. Epub 2011 Apr 27. PubMed PMID: 21523513.

Besheer A, Caysa H, Metz H, Mueller T, Kressler J, Mäder K.
Benchtop-MRI for in vivo imaging using a macromolecular contrast agent based on hydroxyethyl starch (HES). Int J Pharm. 2011 Sep 30;417(1-2):196-203. doi:
10.1016/j.ijpharm.2010.10.051. Epub 2010 Nov 5. PubMed PMID: 21056646.

Mueller LP, Luetzkendorf J, Widder M, Nerger K, Caysa H, Mueller T.
TRAIL-transduced multipotent mesenchymal stromal cells (TRAIL-MSC) overcome TRAIL resistance in selected CRC cell lines in vitro and in vivo. Cancer Gene Ther.
2011 Apr;18(4):229-39. doi: 10.1038/cgt.2010.68. Epub 2010 Oct 29. PubMed PMID: 21037557.

Luetzkendorf J, Mueller LP, Mueller T, Caysa H, Nerger K, Schmoll HJ.
Growth inhibition of colorectal carcinoma by lentiviral TRAIL-transgenic human mesenchymal stem cells requires their substantial intratumoral presence.
J Cell Mol Med. 2010 Sep;14(9):2292-304. doi: 10.1111/j.1582-4934.2009.00794.x. PubMed PMID: 19508388.

Caysa H, Jacob R, Müther N, Branchini B, Messerle M, Söling A.
A redshifted codon-optimized firefly luciferase is a sensitive reporter for bioluminescence imaging.
Photochem Photobiol Sci. 2009 Jan;8(1):52-6. doi: 10.1039/b814566k. Epub 2008 Oct 29. PubMed PMID: 19247529.


Ausgewählte Tagungsbeiträge

Hoffmann S, Caysa H, Vystrcilova L, Etrych T, Ulbrich K, Mueller T, Mäder
K. Polymers as Promising Drug Carrier Systems for Targeted Tumor Therapy - In Vitro Characterization and In Vivo Analyses. Polymeric Materials 2012, Halle (Saale), 2012.

Caysa H, Hoffmann S, Mueller T, Mäder K.
Anwendung von Fluoreszenzfarbstoffen zur Charakterisierung moderner Arzneiformen unter Einbeziehung
präklinischer in vivo Mausmodelle. Innovationsforum: Funktionelle Farbstoffe - Innovation in Medizin und Technik, Bitterfeld-Wolfen, 2012.

Hoffmann S, Vystrcilova L, Ulbrich K, Etrych T, Caysa H, Mueller T, Mäder
K. Tumour Targeted Delivery of Polymer Drug Conjugates with pHSensitive Release: Monitoring the Biodistribution of Carriers and Drug Model Simultaneously by Multispectral Optical Imaging. 9th International
Symposium on Polymer Therapeutics: From Laboratory to Clinical Practice, Valencia, 2012.

Hoffmann S, Vystrcilova L, Ulbrich K, Etrych T, Caysa H, Mueller T, Mäder
K. HPMA Copolymer Drug Conjugates with pH-sensitive Release 76th Prague Meeting on Macromolecules: Polymers in Medicine, Prag, 2012.

Schädlich A, Hoffmann S, Mueller T, Caysa H, Mäder K.
Is the Accumulation of Nanocarriers in the Ovary a Common Phenomenon? 76th Prague Meeting on Macromolecules: Polymers in Medicine, Prag, 2012.

Schobert R, Biersack B, Caysa H, Sassa F, Reipsch F, Mueller T.
Characterisation of new vascular-disrupting agents with antitumor activity.
DGHO Jahrestagung, Basel, 2011.

Hoffmann S, Schädlich A, Caysa H, Mueller, T. and Mäder, K.
HES 450 as Potential Drug Delivery System for Passive Tumor Targeting: An In Vivo Study in NudeMice Using Near Infrared Optical Imaging. European Summerschool in Nanomedicine 2011, Wittenberg, 2011.

Hoffmann S, Schädlich A, Caysa H, Mäder K.
In Vivo Characterisation Of High Molecular Weight Hydroxyethyl Starch Using Noninvasive Fluorescence Imaging. 8th International Symposium on Polymer Therapeutics: From Laboratory to Clinical Practice, Valencia, 2010.

Hoffmann S, Schädlich A, Caysa H, Mäder K.
Plasma Volume expanders as Potential Drug delivery Systems – An in vivo study utilising Noninvasive Near Infrared Fluorescence Optical Imaging. DPhG Jahrestagung, Braunschweig, 2010.

Caysa H, Mäder K , Metz H, Mueller LP, Luetzkendorf J, Schmoll HJ, Mueller T.
Monitoring of xenograft tumour growth and response to chemotherapy by non-invasive in vivo fluorescence imaging. Advanced Drug Delivery, Berlin, 2009.

Luetzkendorf J,Mueller T, Caysa H, Nerger K, Schmoll HJ,Mueller, LP.
TRAILtransgenic human mesenchymal stem cells (MSC) can overcome resistance to soluble TRAIL in colorectal carcinoma (CRC) cells. DGHO Jahrestagung, Heidelberg / Mannheim, 2009.

Besheer A, Vogel J, Caysa H, Groth T, Kressler J, Mäder K.
Comparison of hydrophobically-modified hydroxyethyl starch vs. pluronics as stabilizers of PLGA nanospheres. Controlled Release Society German Chapter Annual Meeting, Braunschweig, 2008.

Caysa H, Mueller T, Mäder K, Metz H.
Benchtop MRI: A new tool for the noninvasive characterisation of drug delivery and cancer in mice.
Controlled Release Society German Chapter Annual Meeting, Braunschweig, 2008.

Caysa H, Mäder K, Metz H, Mueller LP, Luetzkendorf J, Schmoll HJ, Mueller T.
Monitoring of xenograft tumour growth and response to chemotherapy by non-invasive in vivo fluorescence imaging. International Symposium on Polymer Therapeutics, Valencia, 2008.

Kramm CM, Gombert M, Caysa H, Söling A, Hanenberg H.
New 4-Ipomeanol analogues are potent prodrugs of the rabbit cytochrome P450 4B1 suicide gene therapy system in human glioma cells in vivo and in vitro.
Arbeitstagung ”Experimentelle Neuroonkologie“, Oldenburg, 2007.

Müther N, Caysa H, Nagel CH, Sodeik B, Söling A, Messerle M.
Evaluation of the therapeutic effect of oncolytic herpes simplex viruses by bioluminescence imaging.
13. Jahrestagung der Deutschen Gesellschaft für Gentherapie, Düsseldorf, 2006. 1. Posterpreis zuerkannt.

letzte Änderung: Montag, 11. September 2017

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