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Arbeitsgruppe Elastinforschung
 

 

Dr. Andrea Heinz

 

 


Publikationen

Artikel in Fachzeitschriften mit Gutachtersystem:

 

A. Heinz, A.C. Mora Huertas, C.U. Schräder, R. Pankau, A. Gosch, C.E.H. Schmelzer:

Elastins from patients of the Williams-Beuren syndrome and healthy individuals differ on the molecular level,

Am. J. Med. Genet. A, 2016, in press

 

E. Andresen, S. Kroenlein, H.-J. Stärk, U. Riegger, J. Borovec, J. Mattusch, A. Heinz, C.E.H. Schmelzer, Š. Matoušková, B. Dickinson, H. Küpper: Cadmium toxicity investigated on physiological and biophysical level under environmentally relevant conditions using the aquatic model plant Ceratophyllum demersum L., New Phytologist, 2016, in press (Pubmed)

 

I. Bultmann-Mellin, A. Conradi, A. C. Maul, K. Dinger, F. Wempe, A. P. Wohl, T. Imhof, F. T. Wunderlich, A. C. Bunck, T. Nakamura, K. Koli, W. Bloch, A. Ghanem, A. Heinz, H. von Melchner, G. Sengle and A. Sterner-Kock: Modeling Autosomal Recessive Cutis Laxa Type 1c in Mice R-veals Distinct Functions for Ltbp-4 Isoforms, Dis. Model. Mech., 2015, 8, 4, 403-415 (Pubmed)

 

C.U. Schräder, A. Heinz, P. Majovsky, C.E.H. Schmelzer:

Fingerprinting Desmosine-Containing Elastin Peptides,

J. Am. Soc. Mass. Spectrom., 2015, 26, 762-773 (Pubmed)

 

A. Heinz, C.U. Schräder, S. Baud, F.W. Keeley, S.M. Mithieux, A.S. Weiss, R.H.H. Neubert, C.E.H. Schmelzer:

Molecular-level characterization of elastin-like constructs and human aortic elastin,

Matrix Biology, 2014, 38, 12-21 (Pubmed)

 

B. Bochicchio, A. Laurita, A. Heinz, C.E.H. Schmelzer, A. Pepe:
Investigating the role of (2S,4R)-4-hydroxyproline in elastin model peptides,

Biomacromolecules, 2013, 14, 4278-88 (Pubmed)

 

S. Blaise, B. Romier, C. Kawecki, M. Ghirardi, F. Rabenoelina, S. Baud, L. Duca, P. Maurice, A. Heinz, C.E.H. Schmelzer, M. Tarpin, L. Martiny, C. Garbar, M. Dauchez, L. Debelle, V. Durlach:

Elastin-derived peptides, new regulators of insulin resistance development in mice,

Diabetes, 2013, 62, 3807-3816 (Pubmed)

 

A. Heinz, C.K.H. Ruttkies, G. Jahreis, C.U. Schräder, K. Wichapong, W. Sippl, F.W. Keeley, R.H.H. Neubert, C.E.H. Schmelzer:
In vitro cross-linking of elastin peptides and molecular characterization of the resultant biomaterials,

BBA - General Subjects, 2013, 1830, 2994-3004 (Pubmed)

 

C.E.H. Schmelzer, M.C. Jung, J. Wohlrab, R.H.H. Neubert, A. Heinz:

Does human leukocyte elastase degrade intact skin elastin?,

FEBS Journal, 2012, 279, 4191-4200 (Pubmed)

 

S.S. Sivan, B. Van El, Y. Merkher, C.E.H. Schmelzer, A.-M. Zuurmond, A. Heinz, E. Wachtel, P.-P. Varga, A. Lazary, M. Brayda-
Bruno, A. Maroudas: Longevity of elastin in human intervertebral disc as probed by the racemization of aspartic acid,

BBA - General Subjects, 2012, 1820, 1671-1677 (Pubmed)

 

A. Heinz, M.C. Jung, G. Jahreis, A. Rusciani, L. Duca, L. Debelle, A.S. Weiss, R.H.H. Neubert, C.E.H. Schmelzer:

The action of neutrophil serine proteases on elastin and its precursor,

Biochimie, 2012, 94, 192-202 (Pubmed)

 

A.P. McGrath, S.M. Mithieux, C.A. Collyer, J.G. Bakhuis, M. van den Berg, A. Sein, A. Heinz, C. Schmelzer, A.S. Weiss, J.M. Guss:

Structure and Activity of Aspergillus nidulans Copper Amine Oxidase,

Biochemistry, 2011, 50, 5718–5730 (Pubmed)

 

A. Heinz, S. Taddese, W. Sippl, R.H.H. Neubert, C.E.H. Schmelzer:

Insights into the degradation of human elastin by matrilysin-1,

Biochimie, 2011, 93, 2, 187-194 (Pubmed)

 

A. Heinz, M.C. Jung, L. Duca, W. Sippl, S. Taddese, C. Ihling, A. Rusciani, G. Jahreis, A.S. Weiss, R.H.H. Neubert, C.E.H. Schmelzer:
Degradation of tropoelastin by matrix metalloproteinases: cleavage site specificities and release of matrikines,
FEBS Journal, 2010, 277, 8, 1939-1956 (Pubmed)

 

S. Taddese, M.C. Jung, C. Ihling, A. Heinz, R.H.H. Neubert, C.E.H. Schmelzer:

MMP-12 catalytic domain recognizes and cleaves at multiple sites in human skin collagen type I and type III,

BBA - Proteins and Proteomics, 2010, 1804, 4, 731-739 (Pubmed)

 

A. Heinz, C.J. Strachan, K.C. Gordon, T. Rades:
Analysis of solid-state transformations of pharmaceutical compounds using vibrational spectroscopy,
J Pharm Pharmacol, 2009, 61, 6, 971-988 (Pubmed)

 

M. Savolainen, K. Kogermann, A. Heinz, J. Aaltonen, L. Peltonen, C.J. Strachan, J. Yliruusi:
Better understanding of dissolution behaviour of amorphous drugs by in situ solid state analysis using Raman spectroscopy, Eur J Pharm Biopharm, 2009, 71, 1, 71-79 (Pubmed)

 

A. Heinz, K.C. Gordon, C.M. McGoverin, T. Rades, C.J. Strachan:

Understanding the solid state forms of fenofibrate – a spectroscopic and computational study,
Eur J Pharm Biopharm, 2009, 71, 1, 100-108 (Pubmed)

 

A. Heinz, C.J. Strachan, F. Atassi, K.C. Gordon, T. Rades:
Characterizing an amorphous system exhibiting trace crystallinity: a case study with saquinavir,
Cryst Growth Des, 2008, 8, 1, 119-127 (ACS Publications)

 

A. Heinz, M. Savolainen, T. Rades, C.J. Strachan:
Quantifying ternary mixtures of different solid-state forms of indomethacin by Raman and near-infrared spectroscopy,
Eur J Pharm Sci , 2007, 32, 3, 182-192 (Pubmed)

 

M. Savolainen, A. Heinz, C. Strachan, K. C. Gordon, J. Yliruusi, N. Sandler, T. Rades:
Screening for differences in the amorphous state of indomethacin using multivariate visualization,
Eur J Pharm Sci
, 2007, 30, 2, 113-123 (Pubmed)

 

Weitere Publikationen:

 

A. Heinz :

Novel approaches for physicochemical characterisation and quantification of amorphous pharmaceutical compounds,

Dissertation, University of Otago, Dunedin, Neuseeland, 2008

 

A. Heinz :

Entwicklung und Charakterisierung von phospholipidhaltigen W/O-Mikroemulsionen zur dermalen Anwendung"

Diplomarbeit, Martin-Luther-Universität Halle-Wittenberg, 2005

 

Tagungsbeiträge:

 

C.E.H. Schmelzer, C.U. Schräder, T. Hedtke, A. Heinz: Exploring native cross-links in mature elastin, Annual Meeting of the German Society for Matrix Biology, Freiburg, Germany, March 03 – 05, 2016 (Poster)

 

A. Heinz, A.C. Mora Huertas, W. Hoehenwarter, C.E.H. Schmelzer: Investigating the effects of intrinsic and extrinsic aging on human skin elastin, Annual Meeting of the German Society for Matrix Biology,Freiburg, Germany, March 03 – 05, 2016 (Poster)

 

C.U. Schräder, A. Heinz, C. Ihling, C.E.H. Schmelzer: A comprehensive look at the cross-linking pattern of human, bovine and frog elastin, 5th Symposium on Structural Proteomics, Halle, Germany, November 19/20, 2015 (Poster)

 

A.C. Mora Huertas, C.E.H. Schmelzer, C.U. Schräder, A. Heinz: Insights into the age-related changes in elastic fi-bers from skin, 5th Symposium on Structural Proteomics, Halle, Germany, November 19/20, 2015 (Poster)

 

J. Wang, A. Heinz, C.E.H. Schmelzer: Production and characterization of elastin-like biomaterial in vitro cross-linked by lysyl oxidase like 2 protein, 5th Symposium on Structural Proteomics, Halle, Germany, November 19/20, 2015 (Poster)

 

C.U. Schräder, A. Heinz, C.E.H. Schmelzer: Evaluation of native crosslinks in elastin, 48th annual conference of the German Society for Mass Spectrometry, Wuppertal, Germany, March 01 - 04, 2015 (Poster)

 

A. C. Mora Huertas, C.E.H. Schmelzer, C.U. Schräder, R.H.H. Neubert, A. Heinz: Seeking marker peptides for tracking age-related changes in elastic tissues, 48th annual conference of the German Society for Mass Spectrometry, Wuppertal, Germany, March 01 - 04, 2015 (Poster)

 

A. Heinz: Tackling Elastin Cross-Links, 8th European Elastin Meeting, Sept 03 - 06, 2014, Toulouse, France (Invited talk)

 

C.U. Schräder, C.E.H. Schmelzer, W. Höhenwarter, R.H.H. Neubert, A.Heinz: Identification and exact sequence determination of cross-linked peptides released from human aortic elastin, 8th European Elastin Meeting, Sept 03 - 06, 2014, Toulouse, France (Poster)

 

C.U. Schräder, C.E.H. Schmelzer, W. Höhenwarter, R.H.H. Neubert, A. Heinz: Seeking polyfunctionally cross-linked elastin peptides, 47. Diskussionstagung der DGMS, Frankfurt, 02.-05. März 2014 (Poster)

 

C.U. Schräder, C.E.H. Schmelzer, R.H.H. Neubert, A. Heinz: Understanding the fragmentation of elastin peptides cross-linked by desmosine, 26th Meeting of the Israeli Society for Mass Spectrometry, Weizmann Institute, Rehovot, Israel, October 10, 2013 (Poster)

 

C. U. Schräder, C. E. H. Schmelzer, S. Baud, S.M. Mithieux, A. S. Weiss, F.W. Keeley, R.H.H. Neubert, A. Heinz:

Structural characterization of elastin-like biomaterials, Gordon Research Conference Elastin & Elastic Fibers, Biddeford, ME, USA, July 2013 (Poster)

 

M.B.M. Nagel, A. Heinz, S. Sivan, R. Pankau, R.H.H. Neubert, C.E.H. Schmelzer:
Insights into the proline hydroxylation of elastin derived from different tissues and species, 7th Polish-German Symposium on Pharmaceutical Sciences, Gdańsk, May 24-25, 2013 (Poster)

 

M.Q. Köhler, A. Heinz, R.H.H. Neubert, R.H.H. Neubert:

Isolation and Identification of Elastic Fiber Proteins, 7th Polish-German Symposium on Pharmaceutical Sciences, Gdańsk, May 24-25, 2013 (Poster)

 

C.U. Schräder, C.E.H. Schmelzer, S. Baud, A.S. Weiss, R.H.H. Neubert, A. Heinz:
Mass spectrometric characterization of a new elastin-like biomaterial, 7th Polish-German Symposium on Pharmaceutical Sciences, Gdańsk, May 24-25, 2013 (Poster)

 

A. Heinz: Characterizing cross-links of the matrix protein elastin using MALDI-TOF/TOF-mass spectrometry and bioinformatics approaches, Jahrestagung der DPhG, Greifswald, Germany, Oct. 2012 (Oral presentation)

 

C.E.H. Schmelzer, M.C. Jung, S. Sivan, M. Scharm, R. Pankau, R.H.H. Neubert, A. Heinz: Molecular insights into alterations of elastic fibers, 7th European Elastin Meeting, Sept 01 - 04, 2012, Ghent, Belgium (Poster)

 

A. Heinz, C.K.H. Ruttkies, C.U. Schräder, G. Jahreis, F.W. Keeley, S.M. Mithieux, A.S. Weiss, R.H.H. Neubert, C.E.H. Schmelzer: Identification of cross-links in elastin-like biomaterials, 7th European Elastin Meeting, Sept 01 - 04, 2012, Ghent, Belgium (Poster)

 

C.K.H. Ruttkies, C.E.H. Schmelzer, G. Jahreis, M.C. Jung, W. Sippl, R.H.H. Neubert and A. Heinz: Scoring approach for the identification of cross-linked elastin peptides, Mass Spec Europe 2011, Dublin, Ireland, November 2011 (Poster)

 

M. Scharm, M.C. Jung, A . Heinz, R.H.H. Neubert and C.E.H. Schmelzer:

IonHunter - Rapid Biomarker Discovery, Mass Spec Europe 2011, Dublin, Ireland, November 2011 (Poster)

 

A. Heinz, C.K.H. Ruttkies, G. Jahreis, M.C. Jung, W. Sippl, A.S. Weiss, S.M. Mithieux, R.H.H. Neubert and C.E.H. Schmelzer: In vitro formation of elastin cross-links, Gordon Research Conference Elastin & Elastic Fibers, Biddeford, ME, USA, July 2011 (Poster)

 

M.C. Jung, M. Scharm, A . Heinz, R. Pankau, J. Wohlrab, S. Sivan, Y. Merkher, A. Maroudas, R.H.H. Neubert and C.E.H. Schmelzer: Molecular comparison of elastins from different human tissues, Gordon Research Conference Elastin & Elastic Fibers, Biddeford, ME, USA, July 2011 (Poster)

 

M.C Jung, A. Heinz, F. Heyroth, J. Wohlrab, R.H.H. Neubert, C.E.H. Schmelzer:
Isolation and characterization of human elastin, Jahrestagung der DPhG, Braunschweig, 2010 (Poster)

 

M.C. Jung, A. Heinz, J. Wohlrab, F. Heyroth, R.H.H. Neubert, C.E.H. Schmelzer:

Isolation, characterization and structural comparison of elastin from human tissues, 6th European Elastin Meeting, June 28 - July 2, 2010, Maratea, Italy (Poster)

 

A. Heinz, M.C. Jung, L. Duca, W. Sippl, A. Rusciani, R.H.H. Neubert, C.E.H. Schmelzer:

Degradation of elastin by biologically relevant proteases, 6th European Elastin Meeting, June 28 - July 2, 2010, Maratea, Italy (Oral presentation)

 

M.C. Jung, A. Heinz, A. Kiesow, J. Wohlrab, R.H.H. Neubert, C.E.H. Schmelzer: Isolation und Charakterisierung von humanem Hautelastin, 43. Diskussionstagung der DGMS, Halle, March 07 - 10, 2010 (Poster)

 

A. Heinz , M.C. Jung, S. Taddese, C. Ihling, A.S. Weiss, R.H.H. Neubert, C.E.H. Schmelzer: Understanding the degradation of elastin and its precursor, 43. Diskussionstagung der DGMS, Halle, March 07 - 10, 2010 (Poster)

 

S. Taddese, A. Heinz, M.C. Jung, W. Sippl, A.S. Weiss, R.H.H. Neubert, C.E.H. Schmelzer: Insights into the cleavage process of elastin and its precursor by matrix metalloproteinases, Gordon Research Conference Elastin & Elastic Fibers, Biddeford, ME, USA, July 2009 (Poster)

 

M.C. Jung, S. Taddese, C. Ihling, A. Heinz, A.S. Weiss, R.H.H. Neubert, C.E.H. Schmelzer: Proteolytic degradation of human skin collagen by MMP-12, 5th German-Polish Symposium, Poznań, Polen, May 2009 (Poster)

 

A. Heinz, M.C. Jung, S. Taddese, C. Ihling, A.S. Weiss, R.H.H. Neubert, C.E.H. Schmelzer: Using complementary mass spectrometric techniques to determine the cleavage site specificity of elastinolytic proteases, 5th German-Polish Symposium, Poznań, Polen, May 2009 (Poster)

 

A. Heinz , M. Jung, S. Taddese, C. Ihling, A.S. Weiss, R.H.H. Neubert, C.E.H. Schmelzer: Specificity studies of three elastinolytic matrix metalloproteinases, 42. Diskussionstagung der DGMS, Konstanz, March 08 - 11 2009 (Poster)

 

A. Heinz, C.J. Strachan, K.C. Gordon, T. Rades: Insight into different solid-state forms of indomethacin using vibrational spectroscopy, multivariate analysis, and quantum chemical modeling, AAPS Annual Meeting and Exposition, Atlanta, GA, USA, November 16 - 20, 2008 (Poster)

 

M. Savolainen, K. Kogermann, A. Heinz, J. Aaltonen, L. Peltonen, C.J. Strachan, J. Yliruusi: An insight into dissolution behaviour of amorphous drugs by in situ analysis of the solid-state transformations, 19th Helsinki Drug Research, Helsinki, Finland, June 09 - 11, 2008 (Poster)

 

A. Heinz, C.J. Strachan, C.M. McGoverin, K.C. Gordon, T. Rades: Recrystallization of amorphous fenofibrate studied by Raman spectroscopy and multivariate analysis, 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology (PBP), Barcelona, Spain, April 07 - 10, 2008 (Poster)

 

A. Heinz, S.L. Howell, T. Rades, C.J. Strachan:
A molecular-level insight into the structure of crystalline and amorphous fenofibrate, AAPS Annual Meeting and Exposition, San Diego, CA, USA, November 11 - 15, 2007 (Poster)

 

M. Savolainen, A. Heinz, J. Aaltonen, L. Peltonen, C. Strachan, J. Yliruusi: Monitoring solid-state transitions during dissolution testing of amorphous indomethacin, AAPS Annual Meeting and Exposition, San Diego, CA, USA, November 11 - 15, 2007 (Poster)

 

C.J. Strachan, S.L. Howell, A. Heinz, T. Rades, K. Gordon:
Insight into the short range order of amorphous pharmaceutical materials with hydrogen bonding capability using vibrational spectroscopy and computational chemistry, AAPS Annual Meeting and Exposition, San Diego, CA, USA, November 11 - 15, 2007 (Poster)

 

A. Heinz, S.L. Howell, T. Rades, K.C. Gordon, C. J. Strachan:
DFT modelling of solid state structures of a pharmaceutical compound, 7th Australian Conference on Vibrational Spectroscopy (ACOVS-7), Wollongong, Australia, September 26 - 28, 2007 (Poster)

 

A. Heinz, M. Savolainen, C. Strachan, T. Rades:
Quantifying ternary mixtures of different solid state forms of indomethacin by near infrared spectroscopy and partial least squares analysis, 34th Annual Meeting & Exposition of the Controlled Release Society, Long Beach, California, USA, July 7–11, 2007 (Poster)

 

M. Savolainen, A. Heinz, C. Strachan, N. Sandler, T. Rades:
Using multivariate visualization to screen for differences in the stability of amorphous indomethacin, 34th Annual Meeting & Exposition of the Controlled Release Society, Long Beach, California, USA, July 7–11, 2007 (Poster)

 

A. Heinz, M. Savolainen, T. Rades, C. Strachan:
Partial least squares analysis can be used to quantify ternary mixtures of a pharmaceutical compound analyzed by Raman spectroscopy, 10th Scandinavian Symposium on Chemometrics, Lappeenranta, Finland, June 11–15, 2007 (Poster)
Poster Award: “Best Poster in Design of Experiments"

 

M. Savolainen, A. Heinz, C. Strachan, N. Sandler, T. Rades: Using spectroscopic techniques combined with principal component analysis to screen for differences in the stability of amorphous indomethacin, 10th Scandinavian Symposium on Chemometrics, Lappeenranta, Finland, June 11–15, 2007 (Poster)

 

A. Heinz, M. Savolainen, C. Strachan, J. Yliruusi, T. Rades: Development of multivariate models to quantify ternary mixtures of a pharmaceutical compound by Raman and near infrared spectroscopy, 4th International Conference on Advanced Vibrational Spectroscopy, Corfu, Greece, June 10–15, 2007 (Poster)

 

A. Heinz, M. Savolainen, C. Strachan, T. Rades:
Probing the amorphous state of a pharmaceutical compound utilizing vibrational spectroscopy combined with multivariate visualization, 4th International Conference on Advanced Vibrational Spectroscopy, Corfu, Greece, June 10–15, 2007 (Poster)

 

A. Heinz, S. Howell, T. Rades, C. Strachan:
Solid-state analysis using vibrational spectroscopy and computational chemistry,
4th Polish-German Symposium, Halle, Germany, June 06, 2007 (Poster)

 

C. J. Strachan, S. L. Howell, J. A. Zeitler, A. Heinz, J. Rantanen:
Molecular-level insight into dehydration of theophylline by vibrational spectroscopy,
AAPS Annual Meeting and Exposition, San Antonio, TX, USA, October 29 - November 2, 2006 (Poster)

 

M. Savolainen, A. Heinz, C. Strachan, T. Rades, N. Sandler:
Screening of the amorphous state of indomethacin using multivariate visualization,
AAPS Annual Meeting and Exposition, San Antonio, TX, USA, October 29 - November 2, 2006 (Poster)

 

A. Heinz:
Preparation and characterisation of amorphous indomethacin, Formulation and Delivery of Bioactives (FDB) Conference, Dunedin, New Zealand, February 2006 (Vortrag)

 

A. Heinz, M. Savolainen, C. Strachan, N. Sandler, T. Rades:
The solid-state stability of amorphous indomethacin is influenced by the preparation technique, AAPS Annual Meeting and Exposition, San Antonio, TX, USA, October 29 - November 2, 2006 (Poster)

Keywords: Elastin Forschung Hautalterung Alterung Haut elastische Fasern Falten Elastinfasern www.elastin-forschung.de

 
 
 
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