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Arbeitsgruppe Elastinforschung
 

 

Dr. rer. nat. Christian Schmelzer

 



Publikationen

Artikel in Fachzeitschriften mit Gutachtersystem:

 

[35] A. Heinz, A.C. Mora Huertas, C.U. Schräder, R. Pankau, A. Gosch, C.E.H. Schmelzer:

Elastins from patients of the Williams-Beuren syndrome and healthy individuals differ on the molecular level,

Am. J. Med. Genet. A, 2016, in press

 

[34] L. Gorisse, C. Pietrement, V. Vuiblet, C.E.H. Schmelzer, Martin Köhler, Laurent Duca, Laurent Debelle, Paul Fornes, Stéphane Jaisson, Philippe Gillery: Protein carbamylation is a hallmark of aging, PNAS, 2016, in press (Pubmed)

 

[33] E. Andresen, S. Kroenlein, H.-J. Stärk, U. Riegger, J. Borovec, J. Mattusch, A. Heinz, C.E.H. Schmelzer, Š. Matoušková, B. Dickinson, H. Küpper: Cadmium toxicity investigated on physiological and biophysical level under environmentally relevant conditions using the aquatic model plant Ceratophyllum demersum L., New Phytologist, 2016, in press (Pubmed)

 

[32] C.U. Schräder, A. Heinz, P. Majovsky, C.E.H. Schmelzer:

Fingerprinting Desmosine-Containing Elastin Peptides,

J. Am. Soc. Mass. Spectrom., 2015, 26, 762-773 (Pubmed)

 

[31] J. Matysiak, J. Hajduk, L. Pietrzak, C.E.H. Schmelzer, Z.J. Kokot:

Shotgun proteome analysis of honeybee venom using targeted enrichment strategies,

Toxicon, 2014, 90, 255-264 (Pubmed)

 

[30] A. Heinz, C.U. Schräder, S. Baud, F.W. Keeley, S.M. Mithieux, A.S. Weiss, R.H.H. Neubert, C.E.H. Schmelzer:

Molecular-level characterization of elastin-like constructs and human aortic elastin,

Matrix Biology, 2014, 38, 12-21 (Pubmed)

 

[29] D. Bourdetsky, C.E.H. Schmelzer, A. Admon:
The nature and extent of contributions by defective ribosome products to the HLA peptidome,

PNAS, 2014, 111, p.E1591 (Pubmed)

 

[28] B. Bochicchio, A. Laurita, A. Heinz, C.E.H. Schmelzer, A. Pepe:
Investigating the role of (2S,4R)-4-hydroxyproline in elastin model peptides,

Biomacromolecules, 2013, 14, 4278-88 (Pubmed)

 

[27] S. Blaise, B. Romier, C. Kawecki, M. Ghirardi, F. Rabenoelina, S. Baud, L. Duca, P. Maurice, A. Heinz, C.E.H. Schmelzer, M. Tarpin, L. Martiny, C. Garbar, M. Dauchez, L. Debelle, V. Durlach:

Elastin-derived peptides, new regulators of insulin resistance development in mice,

Diabetes, 2013, 62, 3807-3816 (Pubmed)

 

[26] A. Heinz, C.K.H. Ruttkies, G. Jahreis, C.U. Schräder, K. Wichapong, W. Sippl, F.W. Keeley, R.H.H. Neubert, C.E.H. Schmelzer:
In vitro cross-linking of elastin peptides and molecular characterization of the resultant biomaterials,

BBA - General Subjects, 2013, 1830, 2994-3004 (Pubmed)

 

[25] C.E.H. Schmelzer, M.C. Jung, J. Wohlrab, R.H.H. Neubert, A. Heinz:

Does human leukocyte elastase degrade intact skin elastin?,

FEBS Journal, 2012, 279, 4191-4200 (Pubmed)

 

[24] S.S. Sivan, B. Van El, Y. Merkher, C.E.H. Schmelzer, A.-M. Zuurmond, A. Heinz, E. Wachtel, P.-P. Varga, A. Lazary, M. Brayda-Bruno, A. Maroudas: Longevity of elastin in human intervertebral disc as probed by the racemization of aspartic acid, BBA - General Subjects, 2012, 1820, 1671-1677 (Pubmed)

 

[23] S. Smesny, C.E.H. Schmelzer, A. Hinder, A. Köhler, C. Schneider, M. Rudzok, U. Schmidt, B. Milleit, C. Milleit, I. Nenadic, H. Sauer, R.H.H. Neubert, J. Fluhr: Skin ceramide alterations in first-episode schizophrenia indicate abnormal sphingolipid metabolism,

Schizophrenia Bulletin, 2013, 39, 933-941 (Pubmed)

 

[22] A. Heinz, M.C. Jung, G. Jahreis, A. Rusciani, L. Duca, L. Debelle, A.S. Weiss, R.H.H. Neubert, C.E.H. Schmelzer:

The action of neutrophil serine proteases on elastin and its precursor,

Biochimie, 2012, 94, 192-202 (Pubmed)

 

[21] C. Sommer, T.C. Hertel, C.E.H. Schmelzer, M. Pietzsch:
Investigations on the activation of recombinant microbial pro-transglutaminase: in contrast to proteinase K, dispase removes the histidine-tag,

Amino Acids, 2011, 2012, 42, 997-1006 (Pubmed)

 

[20] A.P. McGrath, S.M. Mithieux, C.A. Collyer, J.G. Bakhuis, M. van den Berg, A. Sein, A. Heinz, C. Schmelzer, A.S. Weiss, J.M. Guss:

Structure and Activity of Aspergillus nidulans Copper Amine Oxidase,

Biochemistry, 2011, 50, 5718–5730 (Pubmed)

 

[19] A. Heinz, S. Taddese, W. Sippl, R.H.H. Neubert, C.E.H. Schmelzer:

Insights into the degradation of human elastin by matrilysin-1,

Biochimie, 2011, 93, 2, 187-194 (Pubmed)

 

[18] A. Hinder, C.E.H. Schmelzer, A.V. Rawlings, R.H.H. Neubert:

Investigation of the molecular structure of the human stratum corneum ceramides [NP] and [EOS] by mass spectrometry,

Skin Pharmacology and Physiology, 2011, 24, 3, 127-135 (Pubmed)

 

[17] J. Matysiak, C.E.H. Schmelzer, R.H.H. Neubert, Z.J. Kokot:
Characterization of honeybee venom by MALDI-TOF and nanoESI-QqTOF mass spectrometry,
Journal of Pharmaceutical and Biomedical Analysis, 2011, 54, 2, 273-278 (Pubmed)

 

[16] A. Heinz, M.C. Jung, L. Duca, W. Sippl, S. Taddese, C. Ihling, A. Rusciani, G. Jahreis, A.S. Weiss, R.H.H. Neubert, C.E.H. Schmelzer:
Degradation of tropoelastin by matrix metalloproteinases: cleavage site specificities and release of matrikines,
FEBS Journal, 2010, 277, 8, 1939-1956 (Pubmed)

 

[15] S. Taddese, M.C. Jung, C. Ihling, A. Heinz, R.H.H. Neubert, C.E.H. Schmelzer:

MMP-12 catalytic domain recognizes and cleaves at multiple sites in human skin collagen type I and type III,

BBA - Proteins and Proteomics, 2010, 1804, 4, 731-739 (Pubmed)

 

[14] S. Taddese, A.S. Weiss, G. Jahreis, R.H.H. Neubert, C.E.H. Schmelzer:

In vitro degradation of human tropoelastin by MMP-12 and the generation of matrikines from domain 24,
Matrix Biol., 2009, 28, 2, 84-91 (Pubmed)

 

[13] N. Nass, R. Schöps, R. Ulbrich-Hofmann, A. Simm, L. Hohndorf, C.E.H. Schmelzer, K. Raith, R.H.H. Neubert, K. Eder: Screening for nutritive peptides that modify cholesterol 7-α-hydroxylase expression,
J. Agric. Food Chemistry, 2008, 56, 13, 4987-4994 (Pubmed)

 

[12] S. Taddese, A.S. Weiss, R.H.H. Neubert, C.E.H. Schmelzer:

Mapping of macrophage elastase cleavage sites in insoluble human skin elastin,

Matrix Biol., 2008, 27, 5, 420-428 (Pubmed)

 

[11] S. Gerber, K. Kirchhof, J. Kressler, C.E.H. Schmelzer, C. Scholz, T.C. Hertel, M. Pietzsch:

Cloning, Expression, Purification and Characterization of a Designer Protein with Repetitive Sequences,
Protein Expr. Purif., 2008, 59, 2, 203-215 (Pubmed)

 

[10] H. Farwanah, B. Pierstorff, C.E.H. Schmelzer, K. Raith, R.H.H. Neubert, T. Kolter, K. Sandhoff:

Separation and mass spectrometric characterization of covalently bound skin ceramides using LC/APCI-MS and Nano-ESI-MS, J. Chromatogr. B, 2007, 584, 1-2, 562-570 (Pubmed)

 

[9] C.E.H. Schmelzer, R. Schöps, L. Reynell, R. Ulbrich-Hofmann, R.H.H. Neubert, K. Raith:

Peptic digestion of β-casein - Time course and fate of possible bioactive peptides,
J. Chromatogr. A, 2007, 1166, 1-2, 108-115 (Pubmed)

 

[8] A. Huenerbein, C.E.H. Schmelzer, R.H.H. Neubert:

Real-time monitoring of peptic and tryptic digestions of bovine β-casein using quartz crystal microbalance,

Anal. Chim. Acta, 2007, 584, 1, 72-77 (Pubmed)

 

[7] A. Jäckel, C.E.H. Schmelzer, S. Wartewig, R.H.H. Neubert:
Sublimation of antimycotic agents as proved by various analytical methods,
Pharmazie, 2006, 61, 12, 1045-1047 (Pubmed)

 

[6] K. Raith, C.E.H. Schmelzer, R.H.H. Neubert:

Towards a molecular characterization of pharmaceutical excipients: mass spectrometric investigation of ethoxylated surfactants,
Int. J. Pharm., 2006, 319, 1-2, 1-12 (Pubmed)

 

[5] M. Getie, C.E.H. Schmelzer, A. Weiss, R.H.H. Neubert:

Complementary mass spectrometric techniques to achieve complete sequence coverage of recombinant human tropoelastin,

Rapid Comm. Mass Spectrom., 2005, 19, 20, 2989-2993 (Pubmed)

 

[4] C.E.H. Schmelzer, M. Getie, R.H.H. Neubert:

Mass spectrometric characterization of human skin elastin peptides produced by proteolytic digestion with pepsin and thermitase,

J. Chromatogr. A, 2005, 1083, 1-2, 120-126 (Pubmed)

 

[3] M. Getie, C.E.H. Schmelzer, R.H.H. Neubert:

Characterization of peptides resulting from digestion of human skin elastin with elastase,

Proteins, 2005, 61, 3, 649-657 (Pubmed)

 

[2] C.E.H. Schmelzer, R. Schöps, R. Ulbrich-Hofmann, R.H.H. Neubert, and K. Raith:

Mass spectrometric characterization of peptides derived by peptic cleavage of bovine β-casein,

J. Chromatogr. A, 2004, 1055, 1-2, 87-92 (Pubmed)

 

[1] C.E.H. Schmelzer, W. Zwirbla, E. Rosenfeld, B.B.J. Linde:

Acoustic investigations of pseudo-stable structures in aqueous solutions of polyethylene glycols,

J. Mol. Struct., 2004, 699, 1-3, 47-51 (ScienceDirect)

 

Weitere Publikationen:

 

C.E.H. Schmelzer:

Massenspektrometrische Charakterisierung von Proteinhydrolysaten: Verdaustudien an β-Casein und Strukturuntersuchungen an Elastin,

Dissertation, Martin-Luther-Universität Halle-Wittenberg, 2007 (Link)

 

R. Schöps, R. Körting, N. Naß, C.E.H. Schmelzer:

Physiological-like food protein hydrolysates: a strategy to identify peptides modulating atherosclerosis-relevant factors,
NAFAS, 2005, VOL. 3, 59-64

 

B.B.J. Linde, C.E.H. Schmelzer, E. Rosenfeld, W. Zwirbla:
Ultrasonic Investigation of some Water Mixtures with Non-Electrolytes,
Proceedings of the International Congress of Acoustics, Kyoto 2004, 2609-2610

 

C.E.H. Schmelzer, E. Rosenfeld, B.B.J. Linde:
Acoustical Investigation of Pseudo-Stable Structures in Aqueous Mixtures of Polyethylene Glycol,
Proceedings of the 5th World Congress on Ultrasonics, Paris 2003, 1373-1375 (Link)

 

C.E.H. Schmelzer:

Experimentelle Untersuchungen zu molekularakustischen Eigenschaften von Mischungen aus Wasser und Nichtelektrolyten,

Diplomarbeit, Hochschule Merseburg (FH), 2003, (Link)

 

Ausgewählte Abstracts:

 

M. Getie, C.E.H. Schmelzer, R.H.H. Neubert:

Identification of amino acid sequences for some peptides resulting from enzymatic digestion of human skin elastin,

Matrix Biology, 2004, 23, 6, 402

 

B. Linde, C. Schmelzer, E. Rosenfeld:
Ultrasonic Investigations of Water Mixtures with Polyethylene Glycol 1000,
J. Acoust. Soc. Am., 2002, 112, 5, 2440

 

Tagungsbeiträge:

 

C.E.H. Schmelzer, C.U. Schräder, T. Hedtke, A. Heinz: Exploring native cross-links in mature elastin, Annual Meeting of the German Society for Matrix Biology, Freiburg, Germany, March 03 – 05, 2016 (Poster)

 

L. Gorisse, C. Pietrement, V. Vuiblet, C.E.H. Schmelzer, M. Köhler, L. Duca, L. Debelle, P. Fornes, S. Jaisson, P. Gillery: Carbamylation of matrix proteins as a marker of tissue aging, Annual Meeting of the German Society for Matrix Biology, Freiburg, Germany, March 03 – 05, 2016 (Poster)

 

A. Heinz, A.C. Mora Huertas, W. Hoehenwarter, C.E.H. Schmelzer: Investigating the effects of intrinsic and extrinsic aging on human skin elastin, Annual Meeting of the German Society for Matrix Biology, Freiburg, Germany, March 03 – 05, 2016 (Poster)

 

C.U. Schräder, A. Heinz, C. Ihling, C.E.H. Schmelzer: A comprehensive look at the cross-linking pattern of human, bovine and frog elastin, 5th Symposium on Structural Proteomics, Halle, Germany, November 19/20, 2015 (Poster)

 

A.C. Mora Huertas, C.E.H. Schmelzer, C.U. Schräder, A. Heinz: Insights into the age-related changes in elastic fi-bers from skin, 5th Symposium on Structural Proteomics, Halle, Germany, November 19/20, 2015 (Poster)

 

J. Wang, A. Heinz, C.E.H. Schmelzer: Production and characterization of elastin-like biomaterial in vitro cross-linked by lysyl oxidase like 2 protein, 5th Symposium on Structural Proteomics, Halle, Germany, November 19/20, 2015 (Poster)

 

C.E.H. Schmelzer: Mature Elastin Re-Examined: Identification of Inter- and Intramolecular Cross-Links, Gordon Research Conference Elastin, Elastic Fibers and Microfibrils, Biddeford, ME, USA, July 26-31, 2015

 

C. Kawecki, O. Bocquet, B. Romier-Crouzet, L. Duca, S. Blaise, C. Schmelzer, L. Martiny, L. Debelle, P. Maurice, Development of a proteomic approach for the purification and identification of Neu-1-associated protein com-plexes, Annual Meeting of Société Française de Biologie de la Matrice Extracellulaire, Lyon, France, March 11-13, 2015 (Poster)

C.U. Schräder, A. Heinz, C.E.H. Schmelzer: Evaluation of native crosslinks in elastin, 48th annual conference of the German Society for Mass Spectrometry, Wuppertal, Germany, March 01 - 04, 2015 (Poster)

 

A. C. Mora Huertas, C.E.H. Schmelzer, C.U. Schräder, R.H.H. Neubert, A. Heinz: Seeking marker peptides for tracking age-related changes in elastic tissues, 48th annual conference of the German Society for Mass Spectrometry, Wuppertal, Germany, March 01 - 04, 2015 (Poster)

 

C.U. Schräder, C.E.H. Schmelzer, W. Höhenwarter, R.H.H. Neubert, A.Heinz: Identification and exact sequence determination of cross-linked peptides released from human aortic elastin, 8th European Elastin Meeting, Sept 03 - 06, 2014, Toulouse, France (Poster)

 

C.E.H. Schmelzer: The Fate of Elastic Fibers, 1st Matrix Biology Europe, 21.-24. Juni 2014 (Invited talk)

 

C.U. Schräder, C.E.H. Schmelzer, W. Höhenwarter, R.H.H. Neubert, A. Heinz: Seeking polyfunctionally cross-linked elastin peptides, 47. Diskussionstagung der DGMS, Frankfurt, 02.-05. März 2014 (Poster)

 

C.U. Schräder, C.E.H. Schmelzer, R.H.H. Neubert, A. Heinz: Understanding the fragmentation of elastin peptides cross-linked by desmosine, 26th Meeting of the Israeli Society for Mass Spectrometry, Weizmann Institute, Rehovot, Israel, October 10, 2013 (Poster)

 

C.E.H. Schmelzer: Monitoring changes in elastic fibers, 26th Meeting of the Israeli Society for Mass Spectrometry, Weizmann Institute, Rehovot, Israel, October 10, 2013 (Oral presentation)

 

C.E.H. Schmelzer: We age with our elastic fibers – new insights into molecular changes, XVII Congreso de la Sociedad Española de Histología e Ingeniería Tisular, Logroño, Spain, September 2013 (Invited talk)

 

C.E.H. Schmelzer: Monitoring ageing in elastic fibers, Gordon Research Conference Elastin & Elastic Fibers, Biddeford, ME, USA, July 2013 (Invited talk)

 

C. U. Schräder, C. E. H. Schmelzer, S. Baud, S.M. Mithieux, A. S. Weiss, F.W. Keeley, R.H.H. Neubert, A. Heinz:

Structural characterization of elastin-like biomaterials, Gordon Research Conference Elastin & Elastic Fibers, Biddeford, ME, USA, July 2013 (Poster)

 

M.B.M. Nagel, A. Heinz, S. Sivan, R. Pankau, R.H.H. Neubert, C.E.H. Schmelzer:
Insights into the proline hydroxylation of elastin derived from different tissues and species, 7th Polish-German Symposium on Pharmaceutical Sciences, Gdańsk, May 24-25, 2013 (Poster)

 

M.Q. Köhler, A. Heinz, R.H.H. Neubert, R.H.H. Neubert:

Isolation and Identification of Elastic Fiber Proteins, 7th Polish-German Symposium on Pharmaceutical Sciences, Gdańsk, May 24-25, 2013 (Poster)

 

C.U. Schräder, C.E.H. Schmelzer, S. Baud, A.S. Weiss, R.H.H. Neubert, A. Heinz:
Mass spectrometric characterization of a new elastin-like biomaterial, 7th Polish-German Symposium on Pharmaceutical Sciences, Gdańsk, May 24-25, 2013 (Poster)

 

C.E.H. Schmelzer, M.C. Jung, S. Sivan, M. Scharm, R. Pankau, R.H.H. Neubert, A. Heinz: Molecular insights into alterations of elastic fibers, 7th European Elastin Meeting, Sept 01 - 04, Ghent, 2012, Belgium (Poster)

 

A. Heinz, C.K.H. Ruttkies, C.U. Schräder, G. Jahreis, F.W. Keeley, S.M. Mithieux, A.S. Weiss, R.H.H. Neubert, C.E.H. Schmelzer: Identification of cross-links in elastin-like biomaterials, 7th European Elastin Meeting, Sept 01 - 04, 2012, Ghent, Belgium (Poster)

 

C.K.H. Ruttkies, C.E.H. Schmelzer, G. Jahreis, M.C. Jung, W. Sippl, R.H.H. Neubert and A. Heinz: Scoring approach for the identification of cross-linked elastin peptides, Mass Spec Europe 2011, Dublin, Ireland, November 2011 (Poster)

 

M. Scharm, M.C. Jung, A . Heinz, R.H.H. Neubert and C.E.H. Schmelzer:

IonHunter - Rapid Biomarker Discovery, Mass Spec Europe 2011, Dublin, Ireland, November 2011 (Poster)

 

C.E.H. Schmelzer: Molecular insights into the aging of elastic fibers, Jahrestagung der DPhG, Innsbruck, Austria, Sept. 2011 (Invited talk)

 

A. Heinz, C.K.H. Ruttkies, G. Jahreis, M.C. Jung, W. Sippl, A.S. Weiss, S.M. Mithieux, R.H.H. Neubert and C.E.H. Schmelzer: In vitro formation of elastin cross-links, Gordon Research Conference Elastin & Elastic Fibers, Biddeford, ME, USA, July 2011 (Poster)

 

M.C. Jung, M. Scharm, A . Heinz, R. Pankau, J. Wohlrab, S. Sivan, Y. Merkher, A. Maroudas, R.H.H. Neubert and C.E.H. Schmelzer: Molecular comparison of elastins from different human tissues, Gordon Research Conference Elastin & Elastic Fibers, Biddeford, ME, USA, July 2011 (Poster)

 

M.C Jung, A. Heinz, F. Heyroth, J. Wohlrab, R.H.H. Neubert, C.E.H. Schmelzer:
Isolation and characterization of human elastin, Jahrestagung der DPhG, Braunschweig, 2010 (Poster)

 

M.C. Jung, A. Heinz, J. Wohlrab, F. Heyroth, R.H.H. Neubert, C.E.H. Schmelzer:

Isolation, characterization and structural comparison of elastin from human tissues, 6th European Elastin Meeting, June 28 - July 2, 2010, Maratea, Italy (Poster)

 

A. Heinz, M.C. Jung, L. Duca, W. Sippl, A. Rusciani, R.H.H. Neubert, C.E.H. Schmelzer:

Degradation of elastin by biologically relevant proteases, 6th European Elastin Meeting, June 28 - July 2, 2010, Maratea, Italy (Oral presentation)

 

M.C. Jung, A. Heinz, A. Kiesow, J. Wohlrab, R.H.H. Neubert, C.E.H. Schmelzer:

Isolation und Charakterisierung von humanem Hautelastin, 43. Diskussionstagung der DGMS, Halle, March 07 - 10, 2010 (Poster)

 

A. Heinz , M.C. Jung, S. Taddese, C. Ihling, A.S. Weiss, R.H.H. Neubert, C.E.H. Schmelzer:

Understanding the degradation of elastin and its precursor, 43. Diskussionstagung der DGMS, Halle, March 07 - 10, 2010 (Poster)

 

S. Taddese, A. Heinz, M.C. Jung, W. Sippl, A.S. Weiss, R.H.H. Neubert, C.E.H. Schmelzer:

Insights into the cleavage process of elastin and its precursor by matrix metalloproteinases, Gordon Research Conference Elastin & Elastic Fibers, Biddeford, ME, USA, July 2009 (Poster)

 

S. Taddese, R.H.H. Neubert, C.E.H. Schmelzer:

Pattern of proline hydroxylation in elastin, 5th German-Polish Symposium, Poznań, Polen, May 2009 (Poster)

 

M.C. Jung, S. Taddese, C. Ihling, A. Heinz, A.S. Weiss, R.H.H. Neubert, C.E.H. Schmelzer:
Proteolytic degradation of human skin collagen by MMP-12, 5th German-Polish Symposium, Poznań, Polen, May 2009 (Poster)

 

A. Hinder, C.E.H. Schmelzer, R.H.H. Neubert:

Mass spectrometric characterization of CER[NP] extracted from human stratum corneum, 5th German-Polish Symposium, Poznań, Polen, May 2009 (Poster)

 

J. Matysiak, C.E.H. Schmelzer, R.H.H. Neubert, Z.J. Kokot:

Honeybee venom analysis by MALDI-TOF and Nano-ESI-qTOF mass spectrometry, 5th German-Polish Symposium, Poznań, Polen, May 2009 (Poster)

 

M.E. Zebrowska, Y. Mrestani, H.H. Rüttinger, C.E.H. Schmelzer, M. Sznitowska, R.H.H. Neubert:

Identification and quantification of low-molecular-weight heparins (LMWHS), 5th German-Polish Symposium, Poznań, Polen, May 2009 (Poster)

 

A. Heinz, M.C. Jung, S. Taddese, C. Ihling, A.S. Weiss, R.H.H. Neubert, C.E.H. Schmelzer:
Using complementary mass spectrometric techniques to determine the cleavage site specificity of elastinolytic proteases, 5th German-Polish Symposium, Poznań, Polen, May 2009 (Poster)

 

A. Hinder, C.E.H. Schmelzer, R.H.H. Neubert:

Mass spectrometric characterization of CER[NP] extracted from human stratum corneum,

Controlled Release Society German Chapter Annual Meeting, Halle, 2009 (Vortrag)

 

A. Heinz , M. Jung, S. Taddese, C. Ihling, A.S. Weiss, R.H.H. Neubert, C.E.H. Schmelzer:

Specificity studies of three elastinolytic matrix metalloproteinases,

42. Diskussionstagung der DGMS, Konstanz, 08.-11. März 2009 (Poster)

 

M. Jung, S. Taddese, C. Ihling, R.H.H. Neubert, C.E.H. Schmelzer:

Untersuchungen zum proteolytischen Abbau von Hautkollagenen durch MMP-12,

42. Diskussionstagung der DGMS, Konstanz, 08.-11. März 2009 (Poster)

 

S. Taddese, G. Jahreis, R.H.H. Neubert, C.E.H. Schmelzer:

Generation of matrikines from exon 24-derived sequence of elastin by matrix metalloproteinases,

42. Diskussionstagung der DGMS, Konstanz, 08.-11. März 2009 (Poster)

 

S. Smesny, J.W. Fluhr, P. Sand, C. Schmelzer, A. Hinder, A. Köhler, C. Schneider, M. Rudzok, U. Cyriax, R.H.Neubert, H. Sauer: The Niacin Skin Flush Test: Is Deficient Response Evidence of a Phospholipid Disorder?, The Brain Lipids Conference, 8th-11th September 2008, Oslo, Norway. (Oral presentation)

 

C.E.H. Schmelzer: Susceptibility of tropoelastin and elastin to degradation by matrix metalloproteinases, 5th European Elastin Meeting, Alcala de Henares, Spain, July 16 - 19, 2008 (Invited talk)

 

S. Taddese, A.S. Weiss, R.H.H. Neubert, C.E.H. Schmelzer:

Inhibition of MMP-12 Elastolytic Property Using Low Mass Peptides, 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology (PBP), Barcelona, Spain, April 07 - 10, 2008 (Poster)

 

S. Taddese, A.S. Weiss, R.H.H. Neubert, C.E.H. Schmelzer:
Susceptibility of tropoelastin to macrophage elastase (MMP-12) degradation,
41. Diskussionstagung der DGMS, Gießen, 02.-05. März 2008 (Poster)

 

S. Gerber, K. Kirchhof, J. Kressler, C.E.H. Schmelzer, C. Scholz, T.C. Hertel, M. Pietzsch: Preparation and characterization of an artificial peptide with repetitive sequences. Abstracts of Papers, 234th ACS National Meeting, Boston, MA, United States, August 19-23, 2007, PMSE-018


S. Taddese, R.H.H. Neubert, C.E.H. Schmelzer:
Mass spectrometric characterization of the elastolytic properties of human macrophage elastase (MMP-12) on human skin elastin,
55th ASMS Conference, Indianapolis, IN, USA, 2007 (Poster)

 

S. Taddese, R.H.H. Neubert, C.E.H. Schmelzer:
Degradation of human skin elastin by a major elastinolytic matrix metalloproteinase,

4th Polish-German Symposium, Halle (Saale), 2007 (Poster)

 

K. Raith, C.E.H. Schmelzer, R.H.H. Neubert:

Mass spectrometric characterization of ethoxylated surfactants,

4th Polish-German Symposium, Halle (Saale), 2007 (Poster)

 

N. Nass, R. Schöps, C.E.H. Schmelzer, K. Raith, R.H.H. Neubert, G. Georgi, J.J. Schmitt, A. Simm, R. Ulbrich-Hofmann, K. Eder:

Einfluss von Proteinhydrolysaten auf die Expression der Cholesterol 7α-Hydroxylase in HEP G2-Zellen,

44. Wissenschaftlicher Kongress der DGE, 08.-09.03.2007, Halle (Saale) (Poster)

 

K. Raith, C.E.H. Schmelzer, L. Reynell, R. Schöps, R.H.H. Neubert:
Studies on the digestion of β-casein: how likely is the formation of bioactive peptides?,
DPhG Joint Meeting, 04.-07.10.2006, Marburg (Oral presentation)

 

C.E.H. Schmelzer, L. Reynell, R. Schöps, R.H.H. Neubert, K. Raith:
The time course of peptic digestion of β-casein as studied by LC/MALDI and nanoES mass spectrometry,
HPLC 2006: 30th International Symposium & Exhibit on High Performance Liquid Phase Separations & Related Techniques, San Francisco, CA, USA, 2006 (Poster)

 

C.E.H. Schmelzer, R. Schöps, L. Reynell, R.H.H. Neubert, K. Raith:
Gastro-analogous in vitro digestion of bovine β-casein as studied by nano-ES-MS/MS and MALDI-PSD,
54th ASMS Conference, Seattle, WA, USA, 2006 (Poster)

 

H. Farwanah, B. Pierstorff, S. Brodesser, C.E.H. Schmelzer, K. Raith, R.H.H. Neubert K. Sandhoff:

Normal phase LC/APCI-MS for separation and profiling of stratum corneum ceramides in skin and keratinocytes, 3. Symposium der DFG-Forschergruppe "Keratinocyten", Bonn, 04.05.-05.05.2006 (Poster)

 

K. Raith, C.E.H. Schmelzer, R.H.H. Neubert:
Towards a molecular characterization of pharmaceutical excipients: mass spectrometric studies, of ethoxylatd surfactants,

The First European Congress on Life Science Process Technology in conjunction with TechnoPharm 2005, Nuremberg 2005 (Oral presentation)

 

K. Raith, C.E.H. Schmelzer, A. Huenerbein, R.H.H. Neubert:

MALDI Imaging: Neue Perspektiven in der Pharmazeutischen Forschung,

Jahrestagung der DPhG 2005, Mainz, 07.10.2005 (Oral presentation)

 

A. Huenerbein, C.E.H. Schmelzer, R.H.H. Neubert:
Quartz Crystal Microbalance for On-line Investigations of Enzymatic Reactions on Dietary Proteins,
6th World Congress on Ultrasonics - Ultrasonics International, Beijing, 2005 (Poster)

 

M. Getie, C.E.H. Schmelzer, R.H.H. Neubert:
Determination of the positions of hydroxylated prolines in human skin elastin using mass spectrometry,
Gordon Research Conference on Elastin and Elastic Fibers, Waterville Valley, NH, USA, 2005 (Poster)

 

C.E.H. Schmelzer, M. Getie, K. Raith, R.H.H. Neubert:
Identification of Peptides from Enzymatic Digestion of Human Skin Elastin by Nanoelectrospray Tandem Mass Spectrometry,
53rd ASMS Conference, San Antonio, TX, USA, 2005 (Poster)

 

K. Raith, H. Farwanah, C.E.H. Schmelzer, R.H.H. Neubert:
Tandem Mass Spectrometric Investigation of Esterified Stratum Corneum Ceramides,
53rd ASMS Conference, San Antonio, TX, USA, 2005 (Poster)

 

K. Raith, H. Farwanah, C. Brenner, C.E.H. Schmelzer, R.H.H. Neubert:
LC/APCI-MS in Lipid Analysis,
38. Diskussionstagung der DGMS, Rostock, 06.-09. März 2005 (Poster)

 

M. Getie, C.E.H. Schmelzer, A.S. Weiss, R.H.H. Neubert:
Mass spectrometric characterization of peptides resulting from enzymatic digestion of
recombinant human tropoelastin,
38. Diskussionstagung der DGMS, Rostock, 06.-09. März 2005 (Poster)

 

C.E.H. Schmelzer, A. Huenerbein, K. Raith, R.H.H. Neubert:
MALDI Imaging of Proteins and their Interaction Partners on Surfaces,
38. Diskussionstagung der DGMS, Rostock, 06.-09. März 2005 (Poster)

 

R. Schöps, R. Körting, N. Naß, Ch. Schmelzer, R. Ulbrich-Hofmann:

Physiological-like food protein hydrolysates:
A strategy to identify peptides modulating atherosclerosis-relevant factors,
Health Food Symposium SAS 2004, Toulouse, 21.-22. Oktober 2004 (Oral presentation)

 

C.E.H. Schmelzer, K. Raith, R.H.H. Neubert:
Analytische Charakterisierung von Peptiden aus Proteinverdauen,
BMBF-Statusseminar "Molekulare Ernährungsforschung", Berlin, 20. Sept. 2004 (Poster)

 

M. Getie, C.E.H. Schmelzer, R.H.H. Neubert:
Identification of amino acid sequences for some peptides resulting from enzymatic digestion of human skin elastin using LC/MS/MS,
Third European Symposium Elastin 2004, Manchester, 30. Juni - 3. Juli 2004 (Poster)

 

K. Raith, C.E.H. Schmelzer, R. Schöps, R.H.H. Neubert:
Hydrolysate von Nahrungsproteinen mit Proteasen unterschiedlicher Spezifität: Kombinierter Einsatz von MALDI-PSD und ESI-MS/MS zur Identifizierung von Casein-Fragmenten,
37. Diskussionstagung der DGMS, Leipzig, 07.-10. März 2004 (Oral presentation)

 

C.E.H. Schmelzer, K. Raith, R. Schöps R.H.H. Neubert:
Application of new tools for optimizing the peak detection in MALDI-PSD and ESI-tandem mass spectrometry data for an improvement of the identification quota of peptides from protein hydrolysates,
37. Diskussionstagung der DGMS, Leipzig, 07.-10. März 2004 (Poster)

 

C.E.H. Schmelzer, E. Rosenfeld B.B.J. Linde:
Acoustical Investigation of Pseudo-Stable Structures in Aqueous Mixtures of Polyethylene Glycol,
5th World Congress on Ultrasonics, Paris, 2003 (Poster)

Keywords: Elastin Forschung Hautalterung Alterung Haut elastische Fasern Falten Elastinfasern www.elastin-forschung.de

 
 
 
Webmaster:  Christian Schmelzer Aktualisiert 18.03.2016
 
     
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Naturwissenschaftliche Fakultät I - Biowissenschaften
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