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Arbeitsgruppe Elastinforschung
 

 

Dr. rer. nat. Samuel Taddese

 

 

Pharm. Technologie u. Biopharmazie
Raum 15
Wolfgang-Langenbeck-Str. 4
D-06120 Halle (Saale)

Tel. +49 345 55 25220
Fax +49 345 55 27292

E-mail: Samuel.Mindaye@pharmazie.uni-halle.de

 

Curriculum vitae:

 

20/02/1978   born in Assela, Ethiopia
 
1983-1990   Elementary and Junior Secondary School, Ethiopia
 
1991-1994   High School, Assela Comprehensive Secondary School, Ethiopia
 
1995-2000   B. Pharm, Addis Ababa University (AAU), School of Pharmacy, Ethiopia
 
2000-2001   Graduate Assistant, AAU, School of Pharmacy , Ethiopia
 
2002-2004   MSc. in Pharmaceutics, AAU, Ethiopia
Assistant Lecturer, AAU, School of Pharmacy , Ethiopia
 
2004-2006   Lecturer, School of Pharmacy, AAU, Ethiopia
 
2006-present   Ph.D. student under the supervision of Prof. Dr. Dr. Reinhard Neubert at the Martin Luther University Halle-Wittenberg, Germany
 
Research area:
 
Characterizing the elastolytic properties of elastin degrading matrix metalloproteinases and designing competitive inhibitors
 

Teaching:

 
Practical Courses “Pharmaceutics I” and “Pharmaceutics II/Pharmaceutical Technology”
 
Publications:
 

Peer-reviewed articles in scientific journals:

 
Taddese S, Asres K and Gebre-Mariam T. (2003). Formulation study of topical antimicrobials containing the extracts of Alchemilla pedata and Maesa lanceolata. EPJ 21:13-24
 
Taddese S, Asres K and Gebre-Mariam T. (2003). In vitro antimicrobial activities of some selected topically applied medicinal plants of Ethiopia. EPJ, 21:39-46
 
S. Taddese, A.S. Weiss, R.H.H. Neubert, C.E.H. Schmelzer:
Mapping of macrophage elastase cleavage sites in insoluble human skin elastin,
Matrix Biol., 2008, 27, 5, 420-4282008, 27, 5, 420-428 (Pubmed)
 

S. Taddese, A.S. Weiss, G. Jahreis, R.H.H. Neubert, C.E.H. Schmelzer:
In vitro degradation of human tropoelastin by MMP-12 and the generation of matrikines from domain 24, Matrix Biol., 2009, 28, 2, 84-91 (Pubmed)

 

S. Taddese, M.C. Jung, C. Ihling, A. Heinz, R.H.H. Neubert, C.E.H. Schmelzer:

MMP-12 catalytic domain recognizes and cleaves at multiple sites in human skin collagen type I and type III, BBA - Proteins and Proteomics , 2010, 1804, 4, 731-739 (Pubmed)

 

A. Heinz, M.C. Jung, L. Duca, W. Sippl, S. Taddese, C. Ihling, A. Rusciani, G. Jahreis, A.S. Weiss, R.H.H. Neubert, C.E.H. Schmelzer: Degradation of tropoelastin by matrix metalloproteinases: cleavage site specificities and release of matrikines, FEBS Journal, 2010, 277, 8, 1939-1956 (Pubmed)

 

Conference contribution:

 
S. Taddese, R.H.H. Neubert, C.E.H., Schmelzer. Degradation of human skin elastin by a major elastinolytic matrix metalloproteinase, 4th Polish-German Symposium, Halle (Saale), 2007 (Poster)
 
S. Taddese, R.H.H. Neubert, C.E.H. Schmelzer. Mass spectrometric characterization of the elastolytic properties of human macrophage elastase (MMP-12) on human skin elastin, 55nd ASMS Conference, Indianapolis, IN, USA, 2007 (Poster)
 
S. Taddese, A.S. Weiss, R.H.H. Neubert, C.E.H. Schmelzer:
Susceptibility of tropoelastin to macrophage elastase (MMP-12) degradation,
41. Diskussionstagung der DGMS, Gießen, 02.-05. März 2008 (Poster)
 

S. Taddese, G. Jahreis, R.H.H. Neubert, C.E.H. Schmelzer:

Generation of matrikines from exon 24-derived sequence of elastin by matrix metalloproteinases, 42. Diskussionstagung der DGMS, Konstanz, 08.-11. März 2009 (Poster)

 

M. Jung, S. Taddese, C. Ihling, R.H.H. Neubert, C.E.H. Schmelzer:

Untersuchungen zum proteolytischen Abbau von Hautkollagenen durch MMP-12,

42. Diskussionstagung der DGMS, Konstanz, 08.-11. März 2009 (Poster)

 

A. Heinz , M. Jung, S. Taddese, C. Ihling, A.S. Weiss, R.H.H. Neubert, C.E.H. Schmelzer:

Specificity studies of three elastinolytic matrix metalloproteinases,

42. Diskussionstagung der DGMS, Konstanz, 08.-11. März 2009 (Poster)

 

A. Heinz, M.C. Jung, S. Taddese, C. Ihling, A.S. Weiss, R.H.H. Neubert, C.E.H. Schmelzer:
Using complementary mass spectrometric techniques to determine the cleavage site specificity of elastinolytic proteases, 5th German-Polish Symposium, Poznań, Polen, May 2009 (Poster)

 

M.C. Jung, S. Taddese, C. Ihling, A. Heinz, A.S. Weiss, R.H.H. Neubert, C.E.H. Schmelzer:
Proteolytic degradation of human skin collagen by MMP-12, 5th German-Polish Symposium, Poznań, Polen, May 2009 (Poster)

 

S. Taddese, R.H.H. Neubert, C.E.H. Schmelzer:

Pattern of proline hydroxylation in elastin, 5th German-Polish Symposium, Poznań, Polen, May 2009 (Poster)

 

S. Taddese, A. Heinz, M.C. Jung, W. Sippl, A.S. Weiss, R.H.H. Neubert, C.E.H. Schmelzer:

Insights into the cleavage process of elastin and its precursor by matrix metalloproteinases, Gordon Research Conference Elastin & Elastic Fibers, Biddeford, ME, USA, July 2009 (Poster)

 

A. Heinz , M.C. Jung, S. Taddese, C. Ihling, A.S. Weiss, R.H.H. Neubert, C.E.H. Schmelzer: Understanding the degradation of elastin and its precursor,
43. Diskussionstagung der DGMS, Halle, 07.-10. März 2010 (Poster)

 
 
 
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