Publications
(1995-2006)

Formulation and Characterization of Nanoscopic Pharmaceutical Dosage Forms (Overview Poster)

Development of a Gastric-Resistant Formulation of Omeprazole with Kollicoat MAE 30DP and 100P and Characterization by USP-Resistance-Test and ESR-Spectroscopy
(Poster AAPS, in cooperation with BASF AG, D-Ludwigshafen)

Investigation of the In Vivo Drug Release from Collagen Minirods by ESR
(Poster 32nd Annual Meeting CRS, in cooperation with the LMU München)

Peer-reviewed articles

1. A. Abdalla, K. Mäder:
   Preparation and characterization of a self-emulsifying pellet formulation.
   European Journal of Pharmaceutics and Biopharmaceutics, accepted (2006).
   

2. C. Augsten, K. Mäder:
   Asymmetrische Fluß/Feld-Fluß-Fraktionierung in Verbindung mit Mehrwinkel-Lichtstreudetektion. Eine neue bedeutende Methode der pharmazeutischen Analytik.
   Pharmazeutische Industrie, accepted (2006).
   

3. E. Amado, C. Augsten, K. Mäder, A. Blume, J. Kressler:
   Amphiphilic Water Soluble Triblock Copolymers Based on Poly(2,3-dihydroxypropyl methacrylate) and Poly(propylene oxide): Synthesis by Atom Transfer Radical Polymerization and Micellization in Aqueous Solutions.
   Macromolecules (accepted, 2006).
   

4. S. Strübing, H. Metz, K. Mäder:
   Mechanistic analysis of drug release from tablets with membrane controlled drug delivery.
   European Journal of Pharmaceutics and Biopharmaceutics, accepted (2006)
   

5. A. Beesher, K. Mäder, S. Kaiser, J. Kressler, C. Weis, E.K. Odermatt:
   Tracking of Urinary Excretion of High Molar Mass Poly(vinyl alcohol).
   Journal of Biomedical Materials Research: Part B - Applied Biomaterials, accepted (2006).
   

6. A. Rübe, S. Klein, K. Mäder:
   Monitoring of in vitro fat digestion by Electron Paramagnetic Resonance Spectroscopy.
   Pharmaceutical Research, 23, 2024-2029 (2006).

7. A. Besheer, K.M. Wood, N.A. Peppas, K. Mäder:
   Loading and Mobility of Spin-Labeled Insulin in Physiologically Responsive Complexation Hydrogels Intended for Oral Administration.
   Journal of Controlled Release, 111, 73-80 (2006)
   
   
8. C. Lemarchand, R. Gref, S. Lesieur , H. Hommel, B. Vacher, M. Besnard, A. Besheer, K. Mäder, P. Couvreur:
   Physico-chemical characterization of polysaccharide-coated nanoparticles.
   Journal of Controlled Release 108, 97-111 (2005) .
   
   
9. C. Blümer, K. Mäder:
   Isostatic Ultra High Pressure Effects on Supercooled Melts in Colloidal Lipid Dispersions
   Pharmaceutical Research, 22(10),  1708-15. (2005).
   
   
10. K. Jores, A. Haberland, S. Wartewig, K. Mäder, W. Mehnert:
    Solid lipid nanoparticles (SLN) and oil-loaded SLN as studied by spectrofluorometry and Raman spectroscopy.
    Pharmaceutical Research 22, 1887-1897 (2005).
    
    

11. A. Rübe, G. Hause, K. Mäder, J. Kohlbrecher:
    Core-Shell Structure of Miglyol/Poly(D,L-lactide)/Poloxamer Nanocapsules studied by Small-Angle Neutron Scattering
    Journal of Controlled Release 107, 244-252 (2005).
    
    

12. D.J. Lurie, K. Mäder:
    Monitoring drug delivery processes by EPR and related techniques – principles and applications.
    Advanced Drug Delivery Reviews 57, 1171-1190 (2005).
    
    

13. J.C. Richardson, R.W. Bowtell, K. Mäder, C.D. Melia:
    Pharmaceutical applications of Magnetic Resonance Imaging (MRI).
    Advanced Drug Delivery Reviews 57, 1191-1209 (2005).
    
    

14. K. Mäder:
    Editorial of theme issue “Non-Invasive Spectroscopic and Imaging Techniques in Drug Delivery.”
    Advanced Drug Delivery Reviews 57, 1083-1084 (2005).
    
    

15. A. Rübe, K. Mäder:
    An Electron Spin Resonance Study on the Dynamics of Polymeric Nanocapsules. Journal of Biomedical Nanotechnology. 1 , 208–213 (2005).
    
    

16. C. Augsten, A. Rübe, M.A. Kiselev, R. Gehrke, K. Mäder:
    SAXS study of nanospheres consisting of poly(D,L-lactide-co-glycolide) and a poloxamer shell.
    HASYLAB Annual Report (2004)
    
    

17. A. Lippacher, R.H. Müller, K. Mäder:
    Liquid and semisolid SLN dispersions for topical application: Rheological characterization.
    European Journal of Pharmaceutics and Biopharmaceutics 58 , 561–567 (2004).

    
    

18. K. Jores , W. Mehnert, M. Drechsler , H. Bunjes , C. Johann , K. Mäder: Investigations on the structure of solid lipid nanoparticles (SLN) and oil-loaded solid lipid nanoparticles by photon correlation spectroscopy, field-flow fractionation and transmission electron microscopy.
    Journal of Controlled Release, 95 (2) , 217-227 (2004).
    
    

19. K. Jores, W. Mehnert, K. Mäder:
    Physicochemical investigations on solid lipid nanoparticles (SLN) and on oil-loaded solid lipid nanoparticles: a NMR- and ESR-study.
    Pharmaceutical Research 20 (8), 1274-1283 (2003).
    
    
20. A. Steingötter, P. Kunz, D. Weishaupt, K. Mäder, H. Lengsfeld, M. Thumshirn, P. Boesiger, M. Fried, W. Schwizer:
    Analysis of the meal dependent intragastric performance of a gastric-retentive tablet assessed by magnetic resonance imaging (MRI).
    Alimentary Pharmacology and Therapeutics, 18 (7) 713-720 (2003).
    
    
21. A. Steingötter, D. Weishaupt, P. Kunz, K. Mäder, H. Lengsfeld, M. Thumshirn, P. Boesiger, M. Fried, W. Schwizer:
    Magnetic resonance imaging for the in vivo evaluation of gastric-retentive tablets.
    Pharmaceutical Research, 20 (12) 2001-2007 (2003).
    
    
22. A. Lippacher, R.H. Müller, K. Mäder:
    Semisolid SLN dispersions for topical application: influence of formulation and production parameters on viscoelastic properties.
    European Journal of Pharmaceutics and Biopharmaceutics 53, 155-160 (2002).
    
    
23. W. Mehnert, K. Mäder:
    Solid lipid nanoparticles. Production, characterization and applications.
    Advanced Drug Delivery Reviews 47, 165-196 (2001).
    
    
24. C.Kroll, W. Herrmann, R. Stösser, H.H. Borchert, K. Mäder:
    Influence of drug treatment on the microacidity in rat and human skin – an in vitro electron spin resonance imaging study.
    Pharmaceutical Research 18, 525-530 (2001).
    
    
25. A. Lippacher, R.H. Müller, K. Mäder:
    Preparation of semisolid drug carriers for topical application based on solid lipid nanoparticles.
    International Journal of Pharmaceutics 214, 9-12 (2001).
    
    
26. D. Teomim, K. Mäder, A. Bentolila, A. Magora, A.J. Domb:
    g-Irradiation stability of saturated and unsaturated aliphatic polyanhydrides-Ricinoleic Acid Based Polymers.
    Biomacromolecules 2, 1015-1022 (2001).
    
    
27. B. Gallez, K. Mäder:
    Accurate and sensitive measurements of pO2 in vivo using low frequency EPR spectroscopy: how to confer biocompatibility to the oxygen sensors.
    Free Radical Biology & Medicine 29, 1078-1084 (2000).
    
    
28. A. Lippacher, R.H. Müller, K. Mäder:
    Investigations on the viscoelastic properties of lipid based colloidal drug carriers.
    International Journal of Pharmaceutics, 196, 227-230 (2000).
    
    
29. E. Zimmermann, R. H. Müller, K. Mäder:
    Influence of different parameters on reconstitution of lyophilized SLN
    International Journal of Pharmaceutics 196, 211-213 (2000).
    
    
30. S. Liedtke, S. Wissing, R.H. Müller, K. Mäder:
    Influence of High Pressure Homogenisation Equipment on nanodispersions characteristics.
    International Journal of Pharmaceutics, 196, 183-185 (2000).
    
    
31. I. Katzhendler, K. Mäder, R. Azoury, M. Friedman:
    Investigating the structure and properties of hydrated hydroxypropyl methyl cellulose and egg albumin matrixes containing carbamazepine: EPR and NMR study.
    Pharmaceutical Research, 17, 1299-1308 (2000).
    
    
32. R.H. Müller, K. Mäder, K.; S. Gohla:
    Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art.
    European Journal of Pharmaceutics and Biopharmaceutics 50, 161-177 (2000).
    
    
33. V. Jenning, K. Mäder, S.H. Gohla:
    Solid lipid nanoparticles (SLN) based on binary mixtures of liquid and solid lipids: a 1H-NMR study.
    International Journal of Pharmaceutics 205, 15-21 (2000).
    
    
34. I. Katzhendler, K. Mäder, M. Friedman:
    Correlation between drug release kinetics from protein matrix and matrix structure: EPR and NMR study.
    Journal of Pharmaceutical Sciences, 89, 365-381 (2000).
    
    
35. A. Gessner, R. Waicz, A. Lieske, B.-R. Paulke, K. Mäder, R.H. Müller:
    Nanoparticles with decreasing surface hydrophobicities : Influence on plasma protein absorption.
    International Journal of Pharmaceutics, 196, 245-249 (2000).
    
    
36. K.P. Krause, O. Kayser, K. Mäder, R. Gust, R. H. Müller:
    Heavy metal contamination of nanosuspensions produced by high-pressure homogenisation.
    International Journal of Pharmaceutics, 196, 169-172 (2000).
    
    
37. K. Seehof, M. Kresse, K. Mäder, R.H. Müller:
    Interactions of nanoparticles with body proteins – improvement of 2D-Page analysis by internal standard.
    International Journal of Pharmaceutics, 196, 231-234 (2000).
    
    
38. C. Witt, K. Mäder, T. Kissel:
    The degradation, swelling and erosion properties of biodegradable implants prepared by extrusion or compression moulding of poly(lactide-co-glycolide) and ABA triblock copolymers.
    Biomaterials 21, 931-938 (2000).
    
    
39. I. Katzhendler, K. Mäder, M. Friedman:
    Structure and hydration properties of hydroxypropyl methyl cellulose matrices containing naproxen and naproxen sodium.
    International Journal of Pharmaceutics, 200, 161-179 (2000).
    
    
40. B. Bittner, C. Witt, K. Mäder, T. Kissel:
    Degradation and protein release properties of microspheres prepared from biodegradable poly(lactide-co-glycolide) and ABA triblockcopolymers: Influence of buffer media on polymer erosion and bovine serum albumin release.
    Journal of Controlled Release, 60, 297-309 (1999).
    
    
41. B. Bittner, K. Mäder, C. Kroll, H.H. Borchert, T. Kissel:
    Tetracycline-HCl loaded poly(DL-lactid-coglycolide) microspheres prepared by a spray drying technique: Influence of g-irradiation on radical formation and polymer degradation.
    Journal of Controlled Release, 59, 23-32 (1999).
    
    
42. A. Brunner, K. Mäder, A. Göpferich:
    The microenvironment inside biodegradable microspheres: changes in pH and osmotic pressure.
    Pharmaceutical Research 16, 847-853 (1999).
    
    
43. K. Mäder, B. Bittner, Y. Li, W. Wohlauf, T. Kissel:
    Monitoring microviscosity and microacidity of the albumin microenvironment inside degrading microparticles from polylactide-co-glycolide) (PLG) or ABA -triblock polymers containing hydrophobic poly(lactide-co-glycolide) A blocks and hydrophilic poly(ethylenoxide) B blocks.
    Pharmaceutical Research 15, 787-793 (1998).
    
    
44. K. Mäder:
    Pharmaceutical applications of in vivo EPR.
    Physics in Medicine and Biology, 43, 1-5 (1998).
    
    
45. K. Mäder:
    Monitoring drug release and polymer erosion from therapeutically used biodegradable drug carriers by EPR and MRI in vitro and in vivo.
    Radiology and Oncology, 32, 89-94 (1998).
    
    
46. M. Alecci, K. Mäder, G. Placidi, S. Colacicchi, C. L. Ursini, and A. Sotgiu
    A low frequency EPR model study with pH-sensitive paramagnetic probes for in vivo imaging.
    Physics in Medicine and Biology, 43, 42-48 (1998).
    
    
47. K. Osterloh, C. Kroll, K. Mäder, H.-H. Borchert, B. Sammler, C. Kirmse:
    HPLC und Elektronenspinresonanz-Spektroskopie on-line gekoppelt.
    GIT Labor-Fachzeitschrift, 42, 24-25 (1998).
    
    
48. Karsten Mäder:
    Pharmazeutische Anwendungen der Elektronenspinresonanz-Spektroskopie (ESR).
    PZ Prisma 5, 202-212 (1998).
    
    
49. M.B. Sintzel, K. Schwach-Abdellaoui, K. Mäder, R. Stösser, J. Heller, C. Tabatabay, R. Gurny:
    Influence of irradiation sterilization on semi-solid poly(ortho ester).
    International Journal of Pharmaceutics 175, 165-176 (1998).
    
    
50. K. Mäder, G. Bacic, A. Domb, O. Elmalak, R. Langer, H.M. Swartz:
    Noninvasive in vivo monitoring of drug release and polymer erosion from biodegradable polymers by EPR spectroscopy and NMR imaging.
    Journal of Pharmaceutical Sciences, 86, 126 - 134 (1997).
    
    
51. K. Mäder, S. Nitschke, R. Stösser, H.-H. Borchert, A. Domb:
    Nondestructive and localised assesment of acidic microenvironments inside biodegradable polyanhydrides by spectral spatial Electron Paramagnetic Resonance Imaging (EPRI).
    Polymer 38, 4785-4794 (1997).
    
    
52. K. Mäder, Y. Cremmilleux, A. Domb, J.F. Dunn and H.M. Swartz:
    In vitro / in vivo comparison of drug release and polymer erosion from biodegradable P(FAD-SA) polyanhydrides - a noninvasive approach by the combined use of Electron Paramagnetic Resonance Spectroscopy and Nuclear Magnetic Resonance Imaging.
    Pharmaceutical Research 14, 820-826 (1997).
    
    
53. K.J. Liu, K. Mäder, X. Shi, H.M. Swartz:
    Reduction of carcinogenic Cr(VI) on the skin of living rat.
    Magnetic Resonance in Medicine, 38, 524-526 (1997).
    
    
54. R. Wiesner, J. Rathmann, H.G. Holzhütter, R. Stösser, K. Mäder, H. Nolting, H. Kuhn:
    Nitric oxide oxidises a ferrous mammalien lipoxygenase to a preactivated species.
    FEBS Letters. 389, 229-232, (1996).
    
    
55. B. Gallez, K. Mäder, H.M. Swartz:
    Non-invasive measurement of the pH inside the gut using pH-sensitive nitroxides. An in vivo EPR study.
    Magnetic Resonance in Medicine 36, 694-697 (1996).
    
    
56. K. Mäder, B. Gallez, H.M. Swartz:
    In vivo EPR: An effective new tool for studying pathophysiology, physiology, and pharmacology.
    Applied Radiation and Isotopes, 47, 1663-1667 (1996).
    
    
57. K. Mäder, A. Domb, H.M. Swartz:
    Gamma sterilization induced radicals in biodegradable drug delivery systems.
    Applied Radiation and Isotopes, 47, 1669-1674 (1996).
    
    
58. K. Mäder, B. Gallez, K.J. Liu, H.M.Swartz:
    Noninvasive in vivo characterization of release processes in biodegradable polymers by low frequency Electron Paramagnetic Resonance Spectroscopy.
    Biomaterials, 17, 459-463 (1996).
    
    
59. C. Kroll, K. Mäder, R. Stoesser, H.-H. Borchert:
    Nondestructive determination of pH values in nontransparent W/O systems by means of EPR spectroscopy.
    European Journal of Pharmaceutical Sciences 3, 21-26 (1995).
    
    
60. R. Stösser, K. Mäder, C. Kroll, H.-H. Borchert:
    In vitro and in vivo ESR in S- and X-band to monitor biopharmaceutical processes in mammalian skin.
    Magnetic Resonance in Medicine (Japan) 6, 349-351 (1995).
    
    
61. H.H. Borchert, K. Mäder, R. Stösser, C. Kroll:
    Free radical intermediates in fungal metabolism as a model of mammalien drug metabolism.
    Magnetic Resonance in Medicine (Japan) 6, 375-377 (1995).
    
    
62. K. Mäder, G. Bacic, H.M. Swartz:
    In vivo detection of anthralin derived free radicals in the skin of hairless mice by low frequency electron paramagnetic resonance spectroscopy.
    Journal of Investigative Dermatology, 104, 514-517 (1995).
    
    
63. K. Mäder, H.M. Swartz, R. Stösser, H.-H. Borchert:
    The application of EPR spectroscopy in the field of pharmacy.
    Pharmazie 49 , (2/3), 97-101 (1994).
    
    
64. R. Stoesser, K. Maeder, H.-H. Borchert, R. Lueck:
    High pressure treatment of pharmaceutical drug delivery and related systems. High pressure research 13 , 29-33 (1994).
    
    
65. K. Mäder, R. Stösser, H.-H. Borchert:
    Detection of free radicals in living mice after inhalation of DTBN by X-band ESR. Free Radical Biology & Medicine 14 , 339-342 (1993).
    
    
66. A. Haberland , K. Mäder, R. Stößer, I. Schimke:
    Comparison of malondialdehyde and hydrogen peroxide modified CuZnSOD by EPR spectroscopy.
    Agents Actions 40 , 166-170 (1993).
    
    
67. K. Mäder, R. Stößer, H.-H. Borchert:
    Transcutaneous absorption of nitroxide radicals detected in vivo by means of X-band ESR.
    Pharmazie 47 (12), 946-947 (1992).
    
    
68. K. Mäder, H.-H.Borchert, R. Stößer, N.Groth, T. Herrling:
    Modelluntersuchungen zur Lokalisation und Mobilität von Arzneistoffen in Polymerfolien mit Hilfe der ESR-Tomographie.
    Pharmazie 46 , 439-442 (1991).
    
    
69. K. Mäder, R. Stösser, H.-H. Borchert, R. Mank, B. Nerlich:
    ESR-Untersuchungen zur Wasserpenetration in Polymerfolien und Mikropartikel auf der Basis von biologisch abbaubaren Polyestern.
    Pharmazie 46 , 342 - 345 (1991).

1. A. Besheer, J. Kressler, K. Mäder:
   Nanosized polymers in drug delivery. In Polymeric Nanostructures and Their Applications. (Ed. H. S. Nalwa), American Scientific Publishers, in press (2006).
   
   
2. K. Mäder:
   Solid lipid nanoparticles as drug carriers.
   In: Nanoparticulates as drug carriers. (Ed. V. Torchilin), Imperial College Press, in press (2005).
   
   
3. K. Mäder:
   Characterization of nanoscaled drug delivery systems by Electron Spin Resonance (ESR).
   In: Nanosystem Characterization Tools in the Life Sciences (Ed.: CS.S.R. Kumar, Nanotechnologies for the Life Sciences (Vol. 3), Wiley-VCH, 2005, chapter 7, 241-258.
   
   
4. K. Mäder, W. Mehnert:
   Solid Lipid Nanoparticles - Concepts, Procedures, and Physicochemical Aspects.
   In:Lipospheres in Drug Targets and Delivery. C. Nastruzzi (Ed.), CRC press 2004, 1-22.
   
   
5. K. Mäder, B. Gallez:
   Pharmaceutical applications of in vivo EPR.
   In: Biological Magnetic Resonance, Vol. 20: In Vivo EPR (ESR): Theory and Applications.; Editor: Lawrence J. Berliner, A Kluwer, New York (2003).
   
   
6. H.M. Swartz, K. Mäder:
   Free radicals in aging: theories, facts and artifacts.
   In: Molecular aspects of aging. K. Esser and G.M. Martin (Eds.), John Wiley & Sons, New York, (1995), pp. 77-97.
   
   
7. H.M. Swartz, G. Bacic, K.J. Liu, B. Gallez, K. Mäder, T. Shima, T. Nakashima, J. Jiang, J. O'Hara, T. Walczak:
   In vivo EPR spectroscopy.
   In: H. Ohya-Nishiguchi and L. Packer, (Eds.): Bioradicals detected by ESR Spectroscopy. Birkhäuser Verlag (1995), Basel, pp. 285-299.
   
   
8. R. Stösser, K. Mäder, H.H. Borchert, W. Herrmann, G. Schneider, A. Liero:
   Pharmaceutical Aspects of ESR investigations on drug delivery systems, tissues and living systems.
   In: H. Ohya-Nishiguchi and L. Packer, (Eds.): Bioradicals detected by ESR Spectroscopy. Birkhäuser Verlag (1995), Basel, pp. 301-320.

1. K. Mäder, L.C. Scheibler, H. Steffen:
   Pharmaceutical composition containing fatty acid derivatives for control of dissolution and stability. PCT Int. Appl., WO 0298413 (2002).
   
   
2. K. Mäder, R.E. Martin, S. Raab, L.C. Scheibler, T. Schindler, M. Schröder: Pharmaceutical composition comprising a lipase inhibitor and a sucrose fatty acid ester.PCT Int. Appl. WO 0298412 (2002).
   
   
3. R.H. Müller, S. Wissing, K. Mäder:
   Sunscreens containing UV radiation reflecting or absorbing agents, protecting against harmful UV radiation and reinforcing the natural skin barrier. PCT Int. Appl., WO 0103652 (2001).
   
   
4. R.H. Müller, K. Krause, K. Mäder:
   Method for controlled production of ultrafine microparticles and nanoparticles. PCT Int. Appl., WO 0103670 . (2001)
   
   
5. R.H. Müller, V. Jenning, K. Mäder, A. Lippacher:
   Lipid particles on the basis of mixtures of liquid and solid lipids and method for producing same for drug delivery. PCT Int. Appl. WO 0067728 (2000).
   
   
6. M. Swartz, F. Goda, T. Walczak, K.J. Liu, K. Mäder:
   Apparatus and Methodology for Determining Oxygen in Biological Systems. US 5,706,805 - January 13, (1998).